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KMID : 0043320160390071006
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Archives of Pharmacal Research
2016 Volume.39 No. 7 p.1006 ~ p.1012
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Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model
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Kim Sun-Gun
Lee Eu-Jin
Park Na-Young
Park Hyo-Hyun
Jeong Kyu-Tae
Kim Keuk-Jun
Lee Youn-Ju
Jin Meihua
Lee Eun-Kyung
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Abstract
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We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene compound isolated from Inulae flos, were evaluated in an in vivo animal model for anti-asthma activity through observation of airway hyperresponsiveness (AHR), eosinophil recruitment, Th2 cytokine and IgE levels, and lung histopathology. Britanin administration effectively reduced AHR induced by aerosolized methacholine, airway eosinophilia, Th2 cytokines in bronchoalveolar lavage fluids and the supernatant of cultured splenocytes compared with OVA-induced mice. Histological studies showed that increased inflammatory cell infiltration and mucus secretion were reduced by britanin administration. Thus, britanin may have therapeutic potential for treating allergic asthma.
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KEYWORD
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Inulae flos, Britanin, Airway hyperresponsiveness (AHR), Eosinophils, Bronchoalveolar lavage fluids (BALF)
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